Bionatus

Experimental-BIOTOSS

 

The fluid extract of Mikania glomerata (Guaco) a Brazilian plant is widely used as a syrup to help treat respiratory conditions in children and adults. 

The main chemical composition of Mikania glomerata includes phenolics, mainly coumarin and dihydrocoumarin, and also terpenes including triterpenoids and diterpenes. Throughout the years, large non-clinical researches in academic setting using in vitro or murine models have been conducted.

 

Benzopyrone- like structures such as coumarin and dihydrocoumarin are known to inhibit cycloxygenase enzymic systems and then upstream biosynthesized molecules like prostaglandins and cytokines such as IL-1, IL-2 and TNF-alpha.  Benzopyrones are also known to inhibit various types of edema. Plasma exudation from the bronchial microvasculature and the formation of tissue edema are characteristic features of respiratory tract chronic inflammatory disorders such as asthma. 

 

 ONGOING PROJECTS: 

 

 1. PHYTOTHERAPEUTICS (Traditional ): UNDER REVIEW FOR REGULATORY SUBMISSION 

 2. HYBRID DRUG PRODUCT  and DRUG PRODUCT: NON-CLINICAL STUDIES (Chemistry and in vitro pharmacology )